Angiotensin II Receptor Antagonists - Angiotensin receptor blockers

Angiotensin II Receptor Antagonists - Angiotensin receptor blockers: What is Angiotensin receptor blockers? According to Wikipedia The angiotensin receptor blockers (ARBs), also called angiotensin II receptor antagonists or sartans, are a group of anti-hypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors.

ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy

The discovery and development of ARBs is a demonstrative example of modern rational drug design and how that design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.

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