Prader Willi | Prader Willi Syndrome
Prader Willi | Prader Willi Syndrome . Why May become Prader Willi Syndrome awareness month? According to wiki Prader-Willi syndrome or PWS is a very rare genetic disorder in which seven genes on chromosome 15 are deleted or unexpressed on the paternal chromosome. Prader Willi Syndrome was first described in 1956 by Andrea Prader, Heinrich Willi, Alexis Labhart, Andrew Ziegler, and Guido Fanconi of Switzerland. The incidence of Prader Willi Syndrome is between 1 in 10,000 and 1 in 25,000 live births. The paternal gene origin is lost due to deletion and the maternal genes are silenced due to imprinting. Prader Willi Syndrome has the sister syndrome Angelman syndrome that includes maternally deleted and paternally imprinted genes in the same genetic region. PWS affects approximately 1 in 10,000 to 1 in 25,000 newborns. There are more than 400,000 people who live with PWS around the world. It is traditionally characterized by hypotonia, short stature, hyperphagia, obesity, behavioral iss...